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dc.contributor.authorLiu, Haipeng
dc.contributor.authorIrvine, Darrell J
dc.date.accessioned2017-04-13T19:52:22Z
dc.date.available2017-04-13T19:52:22Z
dc.date.issued2015-05
dc.date.submitted2015-05
dc.identifier.issn1043-1802
dc.identifier.issn1520-4812
dc.identifier.urihttp://hdl.handle.net/1721.1/108144
dc.description.abstractAntigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure–function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.en_US
dc.description.sponsorshipUnited States. National Institutes of Health (AI095109)en_US
dc.description.sponsorshipUnited States. National Institutes of Health (AI091693)en_US
dc.description.sponsorshipUnited States. National Institutes of Health (AI104715)en_US
dc.description.sponsorshipRagon Institute of MGH, MIT and Harvarden_US
dc.description.sponsorshipDana-Farber Cancer Institute. Bridge Projecten_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00103en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleGuiding Principles in the Design of Molecular Bioconjugates for Vaccine Applicationsen_US
dc.typeArticleen_US
dc.identifier.citationLiu, Haipeng, and Darrell J. Irvine. “Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications.” Bioconjugate Chemistry 26, no. 5 (May 20, 2015): 791–801. © 2015 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentRagon Institute of MGH, MIT and Harvarden_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorIrvine, Darrell J
dc.relation.journalBioconjugate Chemistryen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLiu, Haipeng; Irvine, Darrell J.en_US
dspace.embargo.termsNen_US
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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