Radical-mediated ring contraction in the biosynthesis of 7-deazapurines
Author(s)Bandarian, Vahe; Drennan, Catherine L.
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Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
DepartmentMassachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemistry
Current Opinion in Structural Biology
Bandarian, Vahe, and Catherine L Drennan. “Radical-Mediated Ring Contraction in the Biosynthesis of 7-Deazapurines.” Current Opinion in Structural Biology 35 (2015): 116–124.
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