Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Author(s)
Bandarian, Vahe; Drennan, Catherine L.
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Abstract
Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.
Date issued
2015-11
URI
http://hdl.handle.net/1721.1/108672
Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemistry
Journal
Current Opinion in Structural Biology
Publisher
Elsevier
Citation
Bandarian, Vahe, and Catherine L Drennan. “Radical-Mediated Ring Contraction in the Biosynthesis of 7-Deazapurines.” Current Opinion in Structural Biology 35 (2015): 116–124.
Version: Author's final manuscript
ISSN
0959-440X
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