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Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

dc.contributor.authorBandarian, Vahe
dc.contributor.authorDrennan, Catherine L.
dc.date.accessioned2017-05-04T18:21:35Z
dc.date.available2017-05-04T18:21:35Z
dc.date.issued2015-11
dc.identifier.issn0959-440X
dc.identifier.urihttp://hdl.handle.net/1721.1/108672
dc.description.abstractPyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.sbi.2015.11.005en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleRadical-mediated ring contraction in the biosynthesis of 7-deazapurinesen_US
dc.typeArticleen_US
dc.identifier.citationBandarian, Vahe, and Catherine L Drennan. “Radical-Mediated Ring Contraction in the Biosynthesis of 7-Deazapurines.” Current Opinion in Structural Biology 35 (2015): 116–124.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorDrennan, Catherine L.
dc.relation.journalCurrent Opinion in Structural Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBandarian, Vahe; Drennan, Catherine Len_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5486-2755
dspace.mitauthor.errortrue
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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