Virtually Instantaneous, Room-Temperature [[superscript 11]C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes
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Alternative title
Virtually Instantaneous, Room-Temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes
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A new radiosynthetic protocol for the preparation of [[superscript 11]C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [[superscript 11]C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [[superscript 11]C]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency.
Date issued
2015-01Department
Massachusetts Institute of Technology. Department of ChemistryJournal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Lee, Hong Geun, Phillip J. Milner, Michael S. Placzek, Stephen L. Buchwald, and Jacob M. Hooker. "Virtually Instantaneous, Room-Temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes" Journal of the American Chemical Society 137 (2), 2015, pp 648-651.
Version: Author's final manuscript
ISSN
0002-7863
1520-5126