| dc.contributor.author | Placzek, Michael S. | |
| dc.contributor.author | Hooker, Jacob M. | |
| dc.contributor.author | Lee, Hong Geun | |
| dc.contributor.author | Milner, Phillip John | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2017-06-01T20:21:38Z | |
| dc.date.available | 2017-06-01T20:21:38Z | |
| dc.date.issued | 2015-01 | |
| dc.date.submitted | 2014-11 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.issn | 1520-5126 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/109519 | |
| dc.description.abstract | A new radiosynthetic protocol for the preparation of [[superscript 11]C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [[superscript 11]C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [[superscript 11]C]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH GM46059) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (NSF predoctoral fellowship (2010094243)) | en_US |
| dc.description.sponsorship | Amgen Inc. (Educational donation) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH-NIDA postdoctoral fellowship (2T32DA015036)) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ja512115s | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Virtually Instantaneous, Room-Temperature [[superscript 11]C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes | en_US |
| dc.title.alternative | Virtually Instantaneous, Room-Temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Lee, Hong Geun, Phillip J. Milner, Michael S. Placzek, Stephen L. Buchwald, and Jacob M. Hooker. "Virtually Instantaneous, Room-Temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes" Journal of the American Chemical Society 137 (2), 2015, pp 648-651. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Lee, Hong Geun | |
| dc.contributor.mitauthor | Milner, Phillip John | |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Lee, Hong Geun; Milner, Phillip J.; Placzek, Michael S.; Buchwald, Stephen L.; Hooker, Jacob M. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-8075-1100 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
