Divergent Transcription: A Driving Force for New Gene Origination?

Author(s)
Sharp, Phillip A.; Wu, Xuebing, Ph. D. Massachusetts Institute of Technology
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Abstract
The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/109543
Department
Massachusetts Institute of Technology. Computational and Systems Biology Program; Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Cell
Publisher
Elsevier
Citation
Wu, Xuebing and Sharp, Phillip A. “Divergent Transcription: A Driving Force for New Gene Origination?” Cell 155, no. 5 (November 2013): 990–996 © 2013 Elsevier Inc
Version: Author's final manuscript
ISSN
0092-8674
1097-4172
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