Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase

Author(s)
Minnihan, Ellen Catherine; Stubbe, JoAnne; Nocera, Daniel G.
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Abstract
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides (NDPs or NTPs where N = C, U, G, or A) to 2′-deoxynucleotides (dNDPs or dNTPs)[superscript 1] and are responsible for controlling the relative ratios and absolute concentrations of cellular dNTP pools. For this reason, RNRs play a major role in ensuring the fidelity of DNA replication and repair. RNRs are found in all organisms and are classified based on the metallocofactor used to initiate catalysis,[superscript 1] with the class Ia RNRs requiring a diferric-tyrosyl radical (Y•) cofactor.
Date issued
2013-06
URI
http://hdl.handle.net/1721.1/110401
Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemistry
Journal
Accounts of Chemical Research
Publisher
American Chemical Society (ACS)
Citation
Minnihan, Ellen C., Daniel G. Nocera, and JoAnne Stubbe. “Reversible, Long-Range Radical Transfer in E. Coli Class Ia Ribonucleotide Reductase.” Acc. Chem. Res. 46, no. 11 (November 19, 2013): 2524–2535.
Version: Author's final manuscript
ISSN
0001-4842
1520-4898
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