| dc.contributor.author | Minnihan, Ellen Catherine | |
| dc.contributor.author | Stubbe, JoAnne | |
| dc.contributor.author | Nocera, Daniel G. | |
| dc.date.accessioned | 2017-06-30T19:17:44Z | |
| dc.date.available | 2017-06-30T19:17:44Z | |
| dc.date.issued | 2013-06 | |
| dc.date.submitted | 2013-02 | |
| dc.identifier.issn | 0001-4842 | |
| dc.identifier.issn | 1520-4898 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/110401 | |
| dc.description.abstract | Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides (NDPs or NTPs where N = C, U, G, or A) to 2′-deoxynucleotides (dNDPs or dNTPs)[superscript 1] and are responsible for controlling the relative ratios and absolute concentrations of cellular dNTP pools. For this reason, RNRs play a major role in ensuring the fidelity of DNA replication and repair. RNRs are found in all organisms and are classified based on the metallocofactor used to initiate catalysis,[superscript 1] with the class Ia RNRs requiring a diferric-tyrosyl radical (Y•) cofactor. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (GM47274) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (GM29595) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ar4000407 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Minnihan, Ellen C., Daniel G. Nocera, and JoAnne Stubbe. “Reversible, Long-Range Radical Transfer in E. Coli Class Ia Ribonucleotide Reductase.” Acc. Chem. Res. 46, no. 11 (November 19, 2013): 2524–2535. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Minnihan, Ellen Catherine | |
| dc.contributor.mitauthor | Nocera, Daniel G | |
| dc.contributor.mitauthor | Stubbe, JoAnne | |
| dc.relation.journal | Accounts of Chemical Research | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Minnihan, Ellen C.; Nocera, Daniel G.; Stubbe, JoAnne | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-4507-1115 | |
| dc.identifier.orcid | https://orcid.org/0000-0001-8076-4489 | |
| mit.license | PUBLISHER_POLICY | en_US |
