Cell and tissue engineering for liver disease
Author(s)Zaret, K. S.; Fox, I. J.; Bhatia, Sangeeta N; Underhill, Gregory
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Despite the tremendous hurdles presented by the complexity of the liver’s structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.
DepartmentMassachusetts Institute of Technology. Institute for Medical Engineering & Science; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Science Translational Medicine
American Association for the Advancement of Science (AAAS)
Bhatia, S. N., G. H. Underhill, K. S. Zaret, and I. J. Fox. “Cell and Tissue Engineering for Liver Disease.” Science Translational Medicine 6, no. 245 (July 16, 2014): 245sr2–245sr2.
Author's final manuscript