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dc.contributor.authorJia, Xiaoting
dc.contributor.authorGrena, Benjamin
dc.contributor.authorPark, Seongjun
dc.contributor.authorGuo, Yuanyuan
dc.contributor.authorChoe, Han Kyoung
dc.contributor.authorGrena, Benjamin Jean-Baptiste
dc.contributor.authorKang, Jeewoo
dc.contributor.authorPark, Jiyeon
dc.contributor.authorLu, Chi
dc.contributor.authorCanales, Andres
dc.contributor.authorChen, Ritchie
dc.contributor.authorYim, Yeong Shin
dc.contributor.authorChoi, Bohyun Gloria
dc.contributor.authorFink, Yoel
dc.contributor.authorAnikeeva, Polina Olegovna
dc.date.accessioned2017-09-29T18:19:36Z
dc.date.available2017-09-29T18:19:36Z
dc.date.issued2017-02
dc.date.submitted2016-06
dc.identifier.issn1097-6256
dc.identifier.issn1546-1726
dc.identifier.urihttp://hdl.handle.net/1721.1/111655
dc.description.abstractOptogenetic interrogation of neural pathways relies on delivery of light-sensitive opsins into tissue and subsequent optical illumination and electrical recording from the regions of interest. Despite the recent development of multifunctional neural probes, integration of these modalities in a single biocompatible platform remains a challenge. We developed a device composed of an optical waveguide, six electrodes and two microfluidic channels produced via fiber drawing. Our probes facilitated injections of viral vectors carrying opsin genes while providing collocated neural recording and optical stimulation. The miniature ( < 200 μm) footprint and modest weight ( < 0.5 g) of these probes allowed for multiple implantations into the mouse brain, which enabled opto-electrophysiological investigation of projections from the basolateral amygdala to the medial prefrontal cortex and ventral hippocampus during behavioral experiments. Fabricated solely from polymers and polymer composites, these flexible probes minimized tissue response to achieve chronic multimodal interrogation of brain circuits with high fidelity.en_US
dc.description.sponsorshipNational Institute of Neurological Diseases and Stroke (U.S.) (Grant 5R01NS086804)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Award CBET-1253890)en_US
dc.description.sponsorshipNational Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (DMR-1419807)en_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/NN.4510en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleOne-step optogenetics with multifunctional flexible polymer fibersen_US
dc.typeArticleen_US
dc.identifier.citationPark, Seongjun et al. “One-Step Optogenetics with Multifunctional Flexible Polymer Fibers.” Nature Neuroscience 20, no. 4 (February 20, 2017): 612–619. © 2017 Nature America, Inc part of Springer Natureen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorPark, Seongjun
dc.contributor.mitauthorGuo, Yuanyuan
dc.contributor.mitauthorChoe, Han Kyoung
dc.contributor.mitauthorGrena, Benjamin Jean-Baptiste
dc.contributor.mitauthorKang, Jeewoo
dc.contributor.mitauthorPark, Jiyeon
dc.contributor.mitauthorLu, Chi
dc.contributor.mitauthorCanales, Andres
dc.contributor.mitauthorChen, Ritchie
dc.contributor.mitauthorYim, Yeong Shin
dc.contributor.mitauthorChoi, Bohyun Gloria
dc.contributor.mitauthorFink, Yoel
dc.contributor.mitauthorAnikeeva, Polina Olegovna
dc.relation.journalNature Neuroscienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2017-09-28T13:47:01Z
dspace.orderedauthorsPark, Seongjun; Guo, Yuanyuan; Jia, Xiaoting; Choe, Han Kyoung; Grena, Benjamin; Kang, Jeewoo; Park, Jiyeon; Lu, Chi; Canales, Andres; Chen, Ritchie; Yim, Yeong Shin; Choi, Gloria B; Fink, Yoel; Anikeeva, Polinaen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8669-0246
dc.identifier.orcidhttps://orcid.org/0000-0001-7849-7094
dc.identifier.orcidhttps://orcid.org/0000-0003-4419-4292
dc.identifier.orcidhttps://orcid.org/0000-0002-1116-4460
dc.identifier.orcidhttps://orcid.org/0000-0003-3972-7189
dc.identifier.orcidhttps://orcid.org/0000-0003-0946-0401
dc.identifier.orcidhttps://orcid.org/0000-0001-9196-7302
dc.identifier.orcidhttps://orcid.org/0000-0003-4050-8338
dc.identifier.orcidhttps://orcid.org/0000-0001-9752-2283
dc.identifier.orcidhttps://orcid.org/0000-0001-6495-5197
mit.licensePUBLISHER_POLICYen_US


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