VTA neurons coordinate with the hippocampal reactivation of spatial experience
Author(s)Gomperts, Stephen; Kloosterman, Fabian; Wilson, Matthew A
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Spatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role. To test whether the coordination of VTA reward prediction error signals with these replayed spatial sequences could contribute to this process, we recorded from neuronal ensembles of the hippocampus and VTA as rats performed appetitive spatial tasks and subsequently slept. We found that many reward responsive (RR) VTA neurons coordinated with quiet wakefulnessassociated hippocampal SPW-R events that replayed recent experience. In contrast, coordination between RR neurons and SPW-R events in subsequent slow wave sleep was diminished. Together, these results indicate distinct contributions of VTA reinforcement activity associated with hippocampal spatial replay to the processing of wake and SWS-associated spatial memory.
DepartmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
eLife Sciences Publications, Ltd
Gomperts, Stephen N et al. "VTA neurons coordinate with the hippocampal reactivation of spatial experience." eLife 2015, 4 (October): e05360 © 2015 Gomperts et al
Final published version