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dc.contributor.authorGomperts, Stephen
dc.contributor.authorKloosterman, Fabian
dc.contributor.authorWilson, Matthew A
dc.date.accessioned2017-12-13T18:26:03Z
dc.date.available2017-12-13T18:26:03Z
dc.date.issued2015-10
dc.date.submitted2014-10
dc.identifier.urihttp://hdl.handle.net/1721.1/112740
dc.description.abstractSpatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role. To test whether the coordination of VTA reward prediction error signals with these replayed spatial sequences could contribute to this process, we recorded from neuronal ensembles of the hippocampus and VTA as rats performed appetitive spatial tasks and subsequently slept. We found that many reward responsive (RR) VTA neurons coordinated with quiet wakefulnessassociated hippocampal SPW-R events that replayed recent experience. In contrast, coordination between RR neurons and SPW-R events in subsequent slow wave sleep was diminished. Together, these results indicate distinct contributions of VTA reinforcement activity associated with hippocampal spatial replay to the processing of wake and SWS-associated spatial memory.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-MH061976)en_US
dc.description.sponsorshipUnited States. Office of Naval Research (Grant N00014-10-1-0936)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant K08-MH-81207-01A1)en_US
dc.publishereLife Sciences Publications, Ltden_US
dc.relation.isversionofhttp://dx.doi.org/10.7554/eLife.05360.001en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceeLifeen_US
dc.titleVTA neurons coordinate with the hippocampal reactivation of spatial experienceen_US
dc.typeArticleen_US
dc.identifier.citationGomperts, Stephen N et al. "VTA neurons coordinate with the hippocampal reactivation of spatial experience." eLife 2015, 4 (October): e05360 © 2015 Gomperts et alen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.mitauthorGomperts, Stephen
dc.contributor.mitauthorKloosterman, Fabian
dc.contributor.mitauthorWilson, Matthew A
dc.relation.journaleLifeen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2017-12-12T14:55:34Z
dspace.orderedauthorsGomperts, Stephen N; Kloosterman, Fabian; Wilson, Matthew Aen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-7149-3584
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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