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Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

Author(s)
Ruiz-Castillo, Paula; Buchwald, Stephen Leffler
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
Pd-catalyzed cross-coupling reactions that form C-N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C-N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.
Date issued
2016-09
URI
http://hdl.handle.net/1721.1/113056
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Chemical Reviews
Publisher
American Chemical Society (ACS)
Citation
Ruiz-Castillo, Paula and Buchwald, Stephen L. “Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions.” Chemical Reviews 116, 19 (September 2016): 12564–12649 © 2016 American Chemical Society
Version: Final published version
ISSN
0009-2665
1520-6890

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