Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
Author(s)Ruiz-Castillo, Paula; Buchwald, Stephen Leffler
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Pd-catalyzed cross-coupling reactions that form C-N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C-N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Ruiz-Castillo, Paula and Buchwald, Stephen L. “Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions.” Chemical Reviews 116, 19 (September 2016): 12564–12649 © 2016 American Chemical Society
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