Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties
Author(s)
Memic, Adnan; Aldhahri, Musab; Tamayol, Ali; Mostafalu, Pooria; Abdel-wahab, Mohamed Shaaban; Samandari, Mohamadmahdi; Moghaddam, Kamyar Mollazadeh; Annabi, Nasim; Bencherif, Sidi A.; Khademhosseini, Ali; Abdel-wahab, Mohamed; Moghaddam, Kamyar; Bencherif, Sidi; Khademhosseini, Alireza; ... Show more Show less
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Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds from a PGS-PCL composite using a standard electrospinning approach and then coated them with silver (Ag) using a custom radio frequency (RF) sputtering method. The Ag coating formed an electrically conductive layer around the fibers and decreased the pore size. The thickness of the Ag coating could be controlled, thereby tailoring the conductivity of the substrate. The flexible, stretchable patches formed excellent conformal contact with surrounding tissues and possessed excellent pattern-substrate fidelity. In vitro studies confirmed the platform’s biocompatibility and biodegradability. Finally, the potential controlled release of the Ag coating from the composite fibrous scaffolds could be beneficial for many clinical applications. Keywords: electrospinning; electrical properties; nanocoatings; flexible electronics
Date issued
2017-03Department
Institute for Medical Engineering and Science; Harvard University--MIT Division of Health Sciences and TechnologyJournal
Nanomaterials
Publisher
MDPI AG
Citation
Memic, Adnan et al. "Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties." Nanomaterials 7, 3 (2017 March): 63 © 2017 The Author(s)
Version: Final published version
ISSN
2079-4991