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Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions

Author(s)
Dolatshahi-Pirouz, Alireza; Nikkhah, Mehdi; Kolind, Kristian; Dokmeci, Mehmet R.; Khademhosseini, Alireza
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Abstract
As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult to engineer human tissue constructs for transplantation. Recent advances in micro- and nanofabrication techniques have enabled the design of more biomimetic biomaterials that may be used to direct the fate of stem cells. These biomaterials could have a significant impact on the next generation of stem cell based therapies. Here, we highlight the recent progress made by micro- and nanoengineering techniques in the biomaterials field in the context of directing stem cell differentiation. Particular attention is given to the effect of surface topography, chemistry, mechanics and micro- and nanopatterns on the differentiation of embryonic, mesenchymal and neural stem cells. Keywords: micro- and nanotopography; microwells; microarrays; embryonic and adult stem cells; stem cell therapy
Date issued
2011-06
URI
http://hdl.handle.net/1721.1/113375
Department
Institute for Medical Engineering and Science; Harvard University--MIT Division of Health Sciences and Technology
Journal
Journal of Functional Biomaterials
Publisher
MDPI AG
Citation
Dolatshahi-Pirouz, Alireza et al. "Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions." Journal of Functional Biomaterials 2, 3 (June 2011): 88-106 © 2011 The Author(s)
Version: Final published version
ISSN
2079-4983

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