The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition

Author(s)
Feng, Yu-xiong; Sokol, Ethan Samuel; Gupta, Piyush
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Abstract
In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Keywords: EMT; ER stress; UPR
Date issued
2014-10
URI
http://hdl.handle.net/1721.1/116526
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Molecular & Cellular Oncology
Publisher
Informa UK Limited
Citation
Feng, Yu-xiong et al. “The Endoplasmic Reticulum May Be an Achilles’ Heel of Cancer Cells That Have Undergone an Epithelial-to-Mesenchymal Transition.” Molecular & Cellular Oncology 1, 2 (June 2014): e961822 © 2014 The Authors
Version: Final published version
ISSN
2372-3556
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