RNF43 is frequently mutated in colorectal and endometrial cancers
Author(s)Giannakis, Marios; Hodis, Eran; Jasmine Mu, Xinmeng; Yamauchi, Mai; Rosenbluh, Joseph; Cibulskis, Kristian; Saksena, Gordon; Lawrence, Michael S; Qian, Zhi Rong; Nishihara, Reiko; Van Allen, Eliezer M; Hahn, William C; Gabriel, Stacey B; Getz, Gad; Ogino, Shuji; Fuchs, Charles S; Garraway, Levi A; Lander, Eric Steven; ... Show more Show less
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We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.
DepartmentMassachusetts Institute of Technology. Department of Biology
Nature Publishing Group
Giannakis, Marios et al. “RNF43 Is Frequently Mutated in Colorectal and Endometrial Cancers.” Nature Genetics 46, 12 (October 2014): 1264–1266 © 2014 Nature America, Inc
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