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RNF43 is frequently mutated in colorectal and endometrial cancers

dc.contributor.authorGiannakis, Marios
dc.contributor.authorHodis, Eran
dc.contributor.authorJasmine Mu, Xinmeng
dc.contributor.authorYamauchi, Mai
dc.contributor.authorRosenbluh, Joseph
dc.contributor.authorCibulskis, Kristian
dc.contributor.authorSaksena, Gordon
dc.contributor.authorLawrence, Michael S
dc.contributor.authorQian, Zhi Rong
dc.contributor.authorNishihara, Reiko
dc.contributor.authorVan Allen, Eliezer M
dc.contributor.authorHahn, William C
dc.contributor.authorGabriel, Stacey B
dc.contributor.authorGetz, Gad
dc.contributor.authorOgino, Shuji
dc.contributor.authorFuchs, Charles S
dc.contributor.authorGarraway, Levi A
dc.contributor.authorLander, Eric Steven
dc.date.accessioned2018-06-28T19:52:10Z
dc.date.available2018-06-28T19:52:10Z
dc.date.issued2014-10
dc.date.submitted2014-04
dc.identifier.issn1061-4036
dc.identifier.issn1546-1718
dc.identifier.urihttp://hdl.handle.net/1721.1/116687
dc.description.abstractWe report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.en_US
dc.description.sponsorshipNational Human Genome Research Institute (U.S.) (Grant U54HG003067)en_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/NG.3127en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleRNF43 is frequently mutated in colorectal and endometrial cancersen_US
dc.typeArticleen_US
dc.identifier.citationGiannakis, Marios et al. “RNF43 Is Frequently Mutated in Colorectal and Endometrial Cancers.” Nature Genetics 46, 12 (October 2014): 1264–1266 © 2014 Nature America, Incen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorLander, Eric Steven
dc.relation.journalNature Geneticsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-06-28T16:40:52Z
dspace.orderedauthorsGiannakis, Marios; Hodis, Eran; Jasmine Mu, Xinmeng; Yamauchi, Mai; Rosenbluh, Joseph; Cibulskis, Kristian; Saksena, Gordon; Lawrence, Michael S; Qian, Zhi Rong; Nishihara, Reiko; Van Allen, Eliezer M; Hahn, William C; Gabriel, Stacey B; Lander, Eric S; Getz, Gad; Ogino, Shuji; Fuchs, Charles S; Garraway, Levi Aen_US
dspace.embargo.termsNen_US
mit.licensePUBLISHER_POLICYen_US


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