The SUMO guards for SNAIL
Author(s)Ye, Xin; Weinberg, Robert A
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The cell-biological program termed epithelial-mesenchymal transition (EMT) plays a key role in adenocarcinoma progression, invasion, and metastasis. An EMT operating within carcinoma cells can be activated by a variety of paracrine signals arising in the tumor microenvironment. These EMT-inducing signals trigger profound transcription changes through activation of EMT-inducing transcription factors (EMT-TFs), leading to repression of genes associated with the epithelial differentiation program and activation of those associated with the mesenchymal program.
DepartmentMassachusetts Institute of Technology. Department of Biology
Impact Journals, LLC
Ye, Xin, and Robert A. Weinberg. “The SUMO Guards for SNAIL.” Oncotarget 8, no. 58 (November 15, 2017).
Final published version