The SUMO guards for SNAIL

Author(s)
Ye, Xin; Weinberg, Robert A
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Abstract
The cell-biological program termed epithelial-mesenchymal transition (EMT) plays a key role in adenocarcinoma progression, invasion, and metastasis. An EMT operating within carcinoma cells can be activated by a variety of paracrine signals arising in the tumor microenvironment. These EMT-inducing signals trigger profound transcription changes through activation of EMT-inducing transcription factors (EMT-TFs), leading to repression of genes associated with the epithelial differentiation program and activation of those associated with the mesenchymal program.
Date issued
2017-11
URI
http://hdl.handle.net/1721.1/116966
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Oncotarget
Publisher
Impact Journals, LLC
Citation
Ye, Xin, and Robert A. Weinberg. “The SUMO Guards for SNAIL.” Oncotarget 8, no. 58 (November 15, 2017).
Version: Final published version
ISSN
1949-2553
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