Transcriptional Addiction in Cancer
Author(s)Bradner, James E.; Hnisz, Denes; Young, Richard A
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Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.
DepartmentMassachusetts Institute of Technology. Department of Biology
Bradner, James E. et al. “Transcriptional Addiction in Cancer.” Cell 168, 4 (February 2017): 629–643 © 2016 Elsevier
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