| dc.contributor.author | Bradner, James E. | |
| dc.contributor.author | Hnisz, Denes | |
| dc.contributor.author | Young, Richard A. | |
| dc.date.accessioned | 2018-08-06T18:17:13Z | |
| dc.date.available | 2018-08-06T18:17:13Z | |
| dc.date.issued | 2017-02 | |
| dc.identifier.issn | 00928674 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/117285 | |
| dc.description.abstract | Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant HG002668) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | https://doi.org/10.1016/j.cell.2016.12.013 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | Prof. Young | en_US |
| dc.title | Transcriptional Addiction in Cancer | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Bradner, James E. et al. “Transcriptional Addiction in Cancer.” Cell 168, 4 (February 2017): 629–643 © 2016 Elsevier | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.approver | Richard Young | en_US |
| dc.contributor.mitauthor | Young, Richard A | |
| dc.relation.journal | Cell | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Bradner, James E.; Hnisz, Denes; Young, Richard A. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-8855-8647 | |
| mit.license | PUBLISHER_CC | en_US |
