Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer

Author(s)
Fedeles, Bogdan I; Chawanthayatham, Supawadee; Croy, Robert G; Wogan, Gerald N; Essigmann, John M
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Abstract
Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B₁ in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B₁ exposure. Keywords: Duplex sequencing; HCC; hepatocellular carcinoma; mutagenesis; mutational signature; mycotoxins
Date issued
2017-07
URI
http://hdl.handle.net/1721.1/117661
Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemistry
Journal
Molecular & Cellular Oncology
Publisher
Informa UK Limited
Citation
Fedeles, Bogdan I. et al. “Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer.” Molecular & Cellular Oncology 4, 4 (May 2017): e1329693 © 2017 The Author(s)
Version: Final published version
ISSN
2372-3556
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