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Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer

dc.contributor.authorFedeles, Bogdan I
dc.contributor.authorChawanthayatham, Supawadee
dc.contributor.authorCroy, Robert G
dc.contributor.authorWogan, Gerald N
dc.contributor.authorEssigmann, John M
dc.date.accessioned2018-09-07T13:14:04Z
dc.date.available2018-09-07T13:14:04Z
dc.date.issued2017-07
dc.date.submitted2017-05
dc.identifier.issn2372-3556
dc.identifier.urihttp://hdl.handle.net/1721.1/117661
dc.description.abstractUsing duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B₁ in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B₁ exposure. Keywords: Duplex sequencing; HCC; hepatocellular carcinoma; mutagenesis; mutational signature; mycotoxinsen_US
dc.publisherInforma UK Limiteden_US
dc.relation.isversionofhttp://dx.doi.org/10.1080/23723556.2017.1329693en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceTaylor & Francisen_US
dc.titleEarly Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Canceren_US
dc.typeArticleen_US
dc.identifier.citationFedeles, Bogdan I. et al. “Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer.” Molecular & Cellular Oncology 4, 4 (May 2017): e1329693 © 2017 The Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Center for Environmental Health Sciencesen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorFedeles, Bogdan I
dc.contributor.mitauthorChawanthayatham, Supawadee
dc.contributor.mitauthorCroy, Robert G
dc.contributor.mitauthorWogan, Gerald N
dc.contributor.mitauthorEssigmann, John M
dc.relation.journalMolecular & Cellular Oncologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-08-28T18:23:37Z
dspace.orderedauthorsFedeles, Bogdan I.; Chawanthayatham, Supawadee; Croy, Robert G.; Wogan, Gerald N.; Essigmann, John M.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5252-826X
dc.identifier.orcidhttps://orcid.org/0000-0003-0176-1920
dc.identifier.orcidhttps://orcid.org/0000-0003-0771-9889
dc.identifier.orcidhttps://orcid.org/0000-0002-2196-5691
mit.licensePUBLISHER_CCen_US


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