Recent discoveries and applications involving small-molecule microarrays
Author(s)Hong, Jiyoung A; Neel, Dylan V; Wassaf, Dina; Caballero, Francisco; Koehler, Angela Nicole
MetadataShow full item record
High-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications. © 2013 Elsevier Ltd.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biological Engineering
Current Opinion in Chemical Biology
Hong, Jiyoung A., et al. “Recent Discoveries and Applications Involving Small-Molecule Microarrays.” Current Opinion in Chemical Biology, vol. 18, Feb. 2014, pp. 21–28.
Author's final manuscript