The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex

Author(s)
Zhou, Wen; Almeqdadi, Mohammad; Xifaras, Michael; Riddell, Imogen Anne; Yilmaz, Omer; ... Show more
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Abstract
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.
Date issued
2018-02
URI
http://hdl.handle.net/1721.1/117762
Department
Massachusetts Institute of Technology. Department of Chemistry; Koch Institute for Integrative Cancer Research at MIT
Journal
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Citation
Zhou, Wen et al. “The Effect of Geometric Isomerism on the Anticancer Activity of the Monofunctional Platinum Complex Trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃.” Chemical Communications 54, 22 (2018): 2788–2791 © 2018 The Royal Society of Chemistry
Version: Final published version
ISSN
1359-7345
1364-548X
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