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The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex

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The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex

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Author: Zhou, Wen; Almeqdadi, Mohammad; Xifaras, Michael E.; Riddell, Imogen A.; Yilmaz, Ömer H.; Lippard, Stephen J.
Department: Massachusetts Institute of Technology. Department of Chemistry; David H. Koch Institute for Integrative Cancer Research at MIT
Publisher: Royal Society of Chemistry (RSC)
Date Issued: 2018-02
Abstract:
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.
URI: http://hdl.handle.net/1721.1/117762
ISSN: 1359-7345
1364-548X
Citation: Zhou, Wen et al. “The Effect of Geometric Isomerism on the Anticancer Activity of the Monofunctional Platinum Complex Trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃.” Chemical Communications 54, 22 (2018): 2788–2791 © 2018 The Royal Society of Chemistry
Version: Final published version
Terms of Use: Creative Commons Attribution 4.0 International License
Detailed Terms: http://creativecommons.org/licenses/by/4.0/
Published As: http://dx.doi.org/10.1039/C8CC00393A
Journal: Chemical Communications

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