The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex
Author(s)Zhou, Wen; Almeqdadi, Mohammad; Xifaras, Michael; Riddell, Imogen Anne; Yilmaz, Omer; Lippard, Stephen J.; ... Show more Show less
MetadataShow full item record
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemistry
Royal Society of Chemistry (RSC)
Zhou, Wen et al. “The Effect of Geometric Isomerism on the Anticancer Activity of the Monofunctional Platinum Complex Trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃.” Chemical Communications 54, 22 (2018): 2788–2791 © 2018 The Royal Society of Chemistry
Final published version