Show simple item record

The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex

dc.contributor.authorZhou, Wen
dc.contributor.authorAlmeqdadi, Mohammad
dc.contributor.authorXifaras, Michael
dc.contributor.authorRiddell, Imogen Anne
dc.contributor.authorYilmaz, Omer
dc.contributor.authorLippard, Stephen J.
dc.date.accessioned2018-09-14T16:19:36Z
dc.date.available2018-09-14T16:19:36Z
dc.date.issued2018-02
dc.date.submitted2018-01
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/1721.1/117762
dc.description.abstractA trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA034992)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant AG045144)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA034992)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA211184)en_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/C8CC00393Aen_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceRoyal Society of Chemistryen_US
dc.titleThe effect of geometric isomerism on the anticancer activity of the monofunctional platinum complexen_US
dc.typeArticleen_US
dc.identifier.citationZhou, Wen et al. “The Effect of Geometric Isomerism on the Anticancer Activity of the Monofunctional Platinum Complex Trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃.” Chemical Communications 54, 22 (2018): 2788–2791 © 2018 The Royal Society of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorZhou, Wen
dc.contributor.mitauthorAlmeqdadi, Mohammad
dc.contributor.mitauthorXifaras, Michael
dc.contributor.mitauthorRiddell, Imogen Anne
dc.contributor.mitauthorYilmaz, Omer
dc.contributor.mitauthorLippard, Stephen J.
dc.relation.journalChemical Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-09-06T13:52:48Z
dspace.orderedauthorsZhou, Wen; Almeqdadi, Mohammad; Xifaras, Michael E.; Riddell, Imogen A.; Yilmaz, Ömer H.; Lippard, Stephen J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5503-2371
dc.identifier.orcidhttps://orcid.org/0000-0002-6801-0198
dc.identifier.orcidhttps://orcid.org/0000-0002-7577-4612
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
mit.licensePUBLISHER_CCen_US


Files in this item

Thumbnail
Name:
c8cc00393a.pdf
Size:
2.290Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record