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dc.contributor.authorZhou, Wen
dc.contributor.authorAlmeqdadi, Mohammad
dc.contributor.authorXifaras, Michael
dc.contributor.authorRiddell, Imogen Anne
dc.contributor.authorYilmaz, Omer
dc.contributor.authorLippard, Stephen J.
dc.date.accessioned2018-09-14T16:19:36Z
dc.date.available2018-09-14T16:19:36Z
dc.date.issued2018-02
dc.date.submitted2018-01
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/1721.1/117762
dc.description.abstractA trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA034992)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant AG045144)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA034992)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA211184)en_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/C8CC00393Aen_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceRoyal Society of Chemistryen_US
dc.titleThe effect of geometric isomerism on the anticancer activity of the monofunctional platinum complexen_US
dc.typeArticleen_US
dc.identifier.citationZhou, Wen et al. “The Effect of Geometric Isomerism on the Anticancer Activity of the Monofunctional Platinum Complex Trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃.” Chemical Communications 54, 22 (2018): 2788–2791 © 2018 The Royal Society of Chemistryen_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorZhou, Wen
dc.contributor.mitauthorAlmeqdadi, Mohammad
dc.contributor.mitauthorXifaras, Michael
dc.contributor.mitauthorRiddell, Imogen Anne
dc.contributor.mitauthorYilmaz, Omer
dc.contributor.mitauthorLippard, Stephen J.
dc.relation.journalChemical Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-09-06T13:52:48Z
dspace.orderedauthorsZhou, Wen; Almeqdadi, Mohammad; Xifaras, Michael E.; Riddell, Imogen A.; Yilmaz, Ömer H.; Lippard, Stephen J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5503-2371
dc.identifier.orcidhttps://orcid.org/0000-0002-6801-0198
dc.identifier.orcidhttps://orcid.org/0000-0002-7577-4612
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
mit.licensePUBLISHER_CCen_US


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