In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy
Author(s)Jonas, Oliver; Singh, Surya P.; Lammers, Alex; Dasari, Ramachandra R.; So, Peter T. C.; Nguyen, Freddy T.; Langer, Robert S; Cima, Michael J; Kang, Jeon Woong; ... Show more Show less
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We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Laser Biomedical Research Center
Royal Society of Chemistry
Jonas, Oliver, et al. “In Vivo Detection of Drug-Induced Apoptosis in Tumors Using Raman Spectroscopy.” The Analyst, 2018. © 2018 The Royal Society of Chemistry
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