dc.contributor.author | Jonas, Oliver | |
dc.contributor.author | Singh, Surya P. | |
dc.contributor.author | Lammers, Alex | |
dc.contributor.author | Dasari, Ramachandra R. | |
dc.contributor.author | So, Peter T. C. | |
dc.contributor.author | Nguyen, Freddy T. | |
dc.contributor.author | Langer, Robert S | |
dc.contributor.author | Kang, Jeon Woong | |
dc.contributor.author | Cima, Michael J. | |
dc.date.accessioned | 2018-10-01T13:43:13Z | |
dc.date.available | 2018-10-01T13:43:13Z | |
dc.date.issued | 2018-07 | |
dc.date.submitted | 2018-05 | |
dc.identifier.issn | 0003-2654 | |
dc.identifier.issn | 1364-5528 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/118293 | |
dc.description.abstract | We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (9P41EB015871-31) | en_US |
dc.description.sponsorship | Samsung Advanced Institute of Technology | en_US |
dc.description.sponsorship | David H. Koch Institute for Integrative Cancer Research at MIT. Frontier Research Program | en_US |
dc.description.sponsorship | Kathy and Curt Marble Cancer Research Fund | en_US |
dc.description.sponsorship | Brigham and Women's Hospital (Brigham Research Institute Director’s Transformative Award) | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1039/c8an00913a | en_US |
dc.rights | Creative Commons Attribution-NonCommercial 3.0 Unported | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | en_US |
dc.source | Royal Society of Chemistry | en_US |
dc.title | In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Jonas, Oliver, et al. “In Vivo Detection of Drug-Induced Apoptosis in Tumors Using Raman Spectroscopy.” The Analyst, 2018. © 2018 The Royal Society of Chemistry | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Laser Biomedical Research Center | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.mitauthor | Nguyen, Freddy T. | |
dc.contributor.mitauthor | Langer, Robert S | |
dc.contributor.mitauthor | Cima, Michael J | |
dc.contributor.mitauthor | Kang, Jeon Woong | |
dc.relation.journal | The Analyst | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2018-08-22T14:57:41Z | |
dspace.orderedauthors | Jonas, Oliver; Kang, Jeon Woong; Singh, Surya P.; Lammers, Alex; Nguyen, Freddy T.; Dasari, Ramachandra R.; So, Peter T. C.; Langer, Robert; Cima, Michael J. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-0106-8114 | |
dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
dc.identifier.orcid | https://orcid.org/0000-0003-2379-6139 | |
dc.identifier.orcid | https://orcid.org/0000-0003-2012-9023 | |
mit.license | PUBLISHER_CC | en_US |