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In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy

dc.contributor.authorJonas, Oliver
dc.contributor.authorSingh, Surya P.
dc.contributor.authorLammers, Alex
dc.contributor.authorDasari, Ramachandra R.
dc.contributor.authorSo, Peter T. C.
dc.contributor.authorNguyen, Freddy T.
dc.contributor.authorLanger, Robert S
dc.contributor.authorKang, Jeon Woong
dc.contributor.authorCima, Michael J.
dc.date.accessioned2018-10-01T13:43:13Z
dc.date.available2018-10-01T13:43:13Z
dc.date.issued2018-07
dc.date.submitted2018-05
dc.identifier.issn0003-2654
dc.identifier.issn1364-5528
dc.identifier.urihttp://hdl.handle.net/1721.1/118293
dc.description.abstractWe describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (9P41EB015871-31)en_US
dc.description.sponsorshipSamsung Advanced Institute of Technologyen_US
dc.description.sponsorshipDavid H. Koch Institute for Integrative Cancer Research at MIT. Frontier Research Programen_US
dc.description.sponsorshipKathy and Curt Marble Cancer Research Funden_US
dc.description.sponsorshipBrigham and Women's Hospital (Brigham Research Institute Director’s Transformative Award)en_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c8an00913aen_US
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en_US
dc.sourceRoyal Society of Chemistryen_US
dc.titleIn vivo detection of drug-induced apoptosis in tumors using Raman spectroscopyen_US
dc.typeArticleen_US
dc.identifier.citationJonas, Oliver, et al. “In Vivo Detection of Drug-Induced Apoptosis in Tumors Using Raman Spectroscopy.” The Analyst, 2018. © 2018 The Royal Society of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Laser Biomedical Research Centeren_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorNguyen, Freddy T.
dc.contributor.mitauthorLanger, Robert S
dc.contributor.mitauthorCima, Michael J
dc.contributor.mitauthorKang, Jeon Woong
dc.relation.journalThe Analysten_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-08-22T14:57:41Z
dspace.orderedauthorsJonas, Oliver; Kang, Jeon Woong; Singh, Surya P.; Lammers, Alex; Nguyen, Freddy T.; Dasari, Ramachandra R.; So, Peter T. C.; Langer, Robert; Cima, Michael J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0106-8114
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
dc.identifier.orcidhttps://orcid.org/0000-0003-2379-6139
dc.identifier.orcidhttps://orcid.org/0000-0003-2012-9023
mit.licensePUBLISHER_CCen_US


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