3D-resolved targeting of photodynamic therapy using temporal focusing
Author(s)Klein, Oliver; Evans, Conor L; Rowlands, Christopher; Wu, Jacqueline J; Uzel, Sebastien GM; So, Peter T. C.; ... Show more Show less
MetadataShow full item record
A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml-1and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Laser Physics Letters
Rowlands, Christopher J et al. “3D-Resolved Targeting of Photodynamic Therapy Using Temporal Focusing.” Laser Physics Letters 11, 11 (September 2014): 115605 © 2014 Astro Ltd
Final published version