3D-resolved targeting of photodynamic therapy using temporal focusing

Author(s)
Klein, Oliver; Evans, Conor L; Rowlands, Christopher; Wu, Jacqueline J; Uzel, Sebastien GM; ... Show more
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Abstract
A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml-1and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules.
Date issued
2014-09
URI
http://hdl.handle.net/1721.1/120074
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
Laser Physics Letters
Publisher
Wiley Blackwell
Citation
Rowlands, Christopher J et al. “3D-Resolved Targeting of Photodynamic Therapy Using Temporal Focusing.” Laser Physics Letters 11, 11 (September 2014): 115605 © 2014 Astro Ltd
Version: Final published version
ISSN
1612-2011
1612-202X
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