3D-resolved targeting of photodynamic therapy using temporal focusing
Author(s)
Klein, Oliver; Evans, Conor L; Rowlands, Christopher; Wu, Jacqueline J; Uzel, Sebastien GM; So, Peter T. C.; ... Show more Show less
DownloadRowlands_2014_Laser_Phys._Lett._11_115605.pdf (1.276Mb)
PUBLISHER_CC
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml-1and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules.
Date issued
2014-09Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical EngineeringJournal
Laser Physics Letters
Publisher
Wiley Blackwell
Citation
Rowlands, Christopher J et al. “3D-Resolved Targeting of Photodynamic Therapy Using Temporal Focusing.” Laser Physics Letters 11, 11 (September 2014): 115605 © 2014 Astro Ltd
Version: Final published version
ISSN
1612-2011
1612-202X