| dc.contributor.author | Klein, Oliver | |
| dc.contributor.author | Evans, Conor L | |
| dc.contributor.author | Rowlands, Christopher | |
| dc.contributor.author | Wu, Jacqueline J | |
| dc.contributor.author | Uzel, Sebastien GM | |
| dc.contributor.author | So, Peter T. C. | |
| dc.date.accessioned | 2019-01-15T19:17:05Z | |
| dc.date.available | 2019-01-15T19:17:05Z | |
| dc.date.issued | 2014-09 | |
| dc.date.submitted | 2014-06 | |
| dc.identifier.issn | 1612-2011 | |
| dc.identifier.issn | 1612-202X | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/120074 | |
| dc.description.abstract | A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml-1and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant 9P41EB015871-26A1) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01-EX017656) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant 5R01NS051320) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant 4R44EB012415-02) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (Grant CBET-0939511) | en_US |
| dc.publisher | Wiley Blackwell | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1088/1612-2011/11/11/115605 | en_US |
| dc.rights | Creative Commons Attribution 3.0 unported license | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | en_US |
| dc.source | IOP Publishing | en_US |
| dc.title | 3D-resolved targeting of photodynamic therapy using temporal focusing | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Rowlands, Christopher J et al. “3D-Resolved Targeting of Photodynamic Therapy Using Temporal Focusing.” Laser Physics Letters 11, 11 (September 2014): 115605 © 2014 Astro Ltd | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
| dc.contributor.mitauthor | Rowlands, Christopher | |
| dc.contributor.mitauthor | Wu, Jacqueline J | |
| dc.contributor.mitauthor | Uzel, Sebastien GM | |
| dc.contributor.mitauthor | So, Peter T. C. | |
| dc.relation.journal | Laser Physics Letters | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2019-01-03T18:22:24Z | |
| dspace.orderedauthors | Rowlands, Christopher J; Wu, Jackie; Uzel, Sebastien G M; Klein, Oliver; Evans, Conor L; So, Peter T C | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-8261-2371 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-4698-6488 | |
| mit.license | PUBLISHER_CC | en_US |
