| dc.contributor.author | Diaspro, Alberto | |
| dc.contributor.author | Hosseini, Poorya | |
| dc.contributor.author | Zhou, Renjie | |
| dc.contributor.author | Kim, Yang-Hyo | |
| dc.contributor.author | Peres, Chiara | |
| dc.contributor.author | Kuang, Cuifang | |
| dc.contributor.author | Yaqoob, Zahid | |
| dc.contributor.author | So, Peter T. C. | |
| dc.date.accessioned | 2019-02-11T19:03:08Z | |
| dc.date.available | 2019-02-11T19:03:08Z | |
| dc.date.issued | 2016-04 | |
| dc.identifier.issn | 0146-9592 | |
| dc.identifier.issn | 1539-4794 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/120330 | |
| dc.description.abstract | Sensitivity of the amplitude and phasemeasurements in interferometric microscopy is influenced by factors such as instrument design and environmental interferences. Through development of a theoretical framework followed by experimental validation, we show photon shot noise is often the limiting factor in interferometric microscopy measurements. Thereafter,wedemonstratehowa state-of-the-art camera with million-level electrons full well capacity can significantly reduce shot noise contribution resulting in a stability of optical path length down to a few picometers even in a near-common-path interferometer. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (1R01EY017656-06) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (1U01NS090438-01) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (9P41EB015871-28) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (DP3DK101024-01) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (1-R01HL121386-01) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (1R21NS091982-01) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (1U01CA202177-01) | en_US |
| dc.description.sponsorship | Hamamatsu Corporation | en_US |
| dc.description.sponsorship | Singapore-MIT Alliance | en_US |
| dc.description.sponsorship | Skolkovo Foundation | en_US |
| dc.description.sponsorship | Koch Institute for Integrative Cancer Research. Bridge Project Initiative | en_US |
| dc.description.sponsorship | Connecticut Children's Medical Center | en_US |
| dc.description.sponsorship | Samsung Advanced Institute of Technology | en_US |
| dc.publisher | The Optical Society | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1364/OL.41.001656 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Pushing phase and amplitude sensitivity limits in interferometric microscopy | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Hosseini, Poorya, Renjie Zhou, Yang-Hyo Kim, Chiara Peres, Alberto Diaspro, Cuifang Kuang, Zahid Yaqoob, and Peter T. C. So. “Pushing Phase and Amplitude Sensitivity Limits in Interferometric Microscopy.” Optics Letters 41, no. 7 (April 1, 2016): 1656. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Laser Biomedical Research Center | |
| dc.contributor.department | Massachusetts Institute of Technology. Biological Engineering Accelerator Mass Spectrometry Lab | en_US |
| dc.contributor.mitauthor | Hosseini, Poorya | |
| dc.contributor.mitauthor | Zhou, Renjie | |
| dc.contributor.mitauthor | Kim, Yang-Hyo | |
| dc.contributor.mitauthor | Peres, Chiara | |
| dc.contributor.mitauthor | Kuang, Cuifang | |
| dc.contributor.mitauthor | Yaqoob, Zahid | |
| dc.contributor.mitauthor | So, Peter T. C. | |
| dc.relation.journal | Optics Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2019-01-03T19:07:24Z | |
| dspace.orderedauthors | Hosseini, Poorya; Zhou, Renjie; Kim, Yang-Hyo; Peres, Chiara; Diaspro, Alberto; Kuang, Cuifang; Yaqoob, Zahid; So, Peter T. C. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-7347-7887 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-4761-6641 | |
| dc.identifier.orcid | https://orcid.org/0000-0001-5183-576X | |
| dc.identifier.orcid | https://orcid.org/0000-0003-4698-6488 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |