Migration alters oscillatory dynamics and promotes survival in connected bacterial populations
Author(s)
Ranjan, Tanvi; Gokhale, Shreyas Shashank; Conwill, Arolyn Macdonald; Gore, Jeff
Downloads41467-018-07703-y.pdf (1.628Mb)
PUBLISHER_CC
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
Migration influences population dynamics on networks, thereby playing a vital role in scenarios ranging from species extinction to epidemic propagation. While low migration rates prevent local populations from becoming extinct, high migration rates enhance the risk of global extinction by synchronizing the dynamics of connected populations. Here, we investigate this trade-off using two mutualistic strains of E. coli that exhibit population oscillations when co-cultured. In experiments, as well as in simulations using a mechanistic model, we observe that high migration rates lead to synchronization whereas intermediate migration rates perturb the oscillations and change their period. Further, our simulations predict, and experiments show, that connected populations subjected to more challenging antibiotic concentrations have the highest probability of survival at intermediate migration rates. Finally, we identify altered population dynamics, rather than recolonization, as the primary cause of extended survival.
Date issued
2018-12Department
Massachusetts Institute of Technology. Department of PhysicsJournal
Nature Communications
Publisher
Nature Publishing Group
Citation
Gokhale, Shreyas et al. “Migration Alters Oscillatory Dynamics and Promotes Survival in Connected Bacterial Populations.” Nature Communications 9, 1 (December 2018): 5273 © 2018 The Author(s)
Version: Final published version
ISSN
2041-1723