Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman

Author(s)
de Carlo, Talisa E.; Adhi, Mehreen; Lu, Chen David; Duker, Jay S.; Fujimoto, James G; ... Show more
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Abstract
We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto fluorescence demonstrated hyperautofluorescent at the deposits. Fluorescein angiography revealed mild hyperfluorescence and staining of the lesions. Spectral-domain optical coherence tomography (SD-OCT) OS showed accumulations in the temporal macula at Bruch's membrane. UHR-OCT provided improved axial resolution compared to the standard 5 μm on the commercial SD-OCT and confirmed the presence of deposits in Bruch's membrane, consistent with drusen. The retinal layers were draped over the excrescences but did not show any disruption. Keywords: Drusen; Optical Coherence Tomography; Retinal Imaging; Retina
Date issued
2015-10
URI
https://hdl.handle.net/1721.1/121523
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Research Laboratory of Electronics
Journal
Clinical Medical Reviews and Case Reports
Publisher
ClinMed International Library
Citation
de Carlo Talisa E. et al. "Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman." Clinical Medical Reviews and Case Reports 2, 10 (October 2015): CMRCR-2-063 © 2015 The Authors
Version: Final published version
ISSN
2378-3656
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