| dc.contributor.author | de Carlo, Talisa E. | |
| dc.contributor.author | Adhi, Mehreen | |
| dc.contributor.author | Lu, Chen David | |
| dc.contributor.author | Duker, Jay S. | |
| dc.contributor.author | Fujimoto, James G | |
| dc.contributor.author | Waheed, Nadia K. | |
| dc.date.accessioned | 2019-07-08T20:23:04Z | |
| dc.date.available | 2019-07-08T20:23:04Z | |
| dc.date.issued | 2015-10 | |
| dc.date.submitted | 2015-08 | |
| dc.identifier.issn | 2378-3656 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/121523 | |
| dc.description.abstract | We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto fluorescence demonstrated hyperautofluorescent at the deposits. Fluorescein angiography revealed mild hyperfluorescence and staining of the lesions. Spectral-domain optical coherence tomography (SD-OCT) OS showed accumulations in the temporal macula at Bruch's membrane. UHR-OCT provided improved axial resolution compared to the standard 5 μm on the commercial SD-OCT and confirmed the presence of deposits in Bruch's membrane, consistent with drusen. The retinal layers were draped over the excrescences but did not show any disruption. Keywords: Drusen; Optical Coherence Tomography; Retinal Imaging; Retina | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01-EY011289-29) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R44-EY022864-02) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01-CA075289-17) | en_US |
| dc.description.sponsorship | Air Force Office of Scientific Research (Grant FA9550-10-1-0551) | en_US |
| dc.description.sponsorship | Air Force Office of Scientific Research (Grant FA9550-12-1-0499) | en_US |
| dc.language.iso | en | |
| dc.publisher | ClinMed International Library | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.23937/2378-3656/1410063 | en_US |
| dc.rights | Creative Commons Attribution 4.0 International license | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Clinical Medical Reviews and Case Reports | en_US |
| dc.title | Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | de Carlo Talisa E. et al. "Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman." Clinical Medical Reviews and Case Reports 2, 10 (October 2015): CMRCR-2-063 © 2015 The Authors | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Research Laboratory of Electronics | en_US |
| dc.relation.journal | Clinical Medical Reviews and Case Reports | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2019-06-21T17:47:02Z | |
| dspace.date.submission | 2019-06-21T17:47:03Z | |
| mit.journal.volume | 2 | en_US |
| mit.journal.issue | 10 | en_US |
| mit.license | PUBLISHER_CC | |
