Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

Author(s)
Luo, X.; Wang, Wei; Dorkin, Joseph Robert; Veiseh, Omid; Chang, Pyung-Hun; ... Show more
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Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
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Abstract
Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.
Date issued
2017-01
URI
https://hdl.handle.net/1721.1/121985
Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Koch Institute for Integrative Cancer Research at MIT
Journal
Biomaterials Science
Publisher
Royal Society of Chemistry (RSC)
Citation
Luo, X. et al. "Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo." Biomaterials Science 1 (January 2017): 38-40 © 2017 The Royal Society of Chemistry
Version: Author's final manuscript
ISSN
2047-4830
2047-4849
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