Show simple item record

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

dc.contributor.authorLuo, X.
dc.contributor.authorWang, Wei
dc.contributor.authorDorkin, Joseph Robert
dc.contributor.authorVeiseh, Omid
dc.contributor.authorChang, Pyung-Hun
dc.contributor.authorAbutbul-Ionita, I.
dc.contributor.authorDanino, D.
dc.contributor.authorLanger, Robert S
dc.contributor.authorAnderson, Daniel Griffith
dc.contributor.authorDong, Y.
dc.date.accessioned2019-08-13T15:55:27Z
dc.date.available2019-08-13T15:55:27Z
dc.date.issued2017-01
dc.date.submitted2016-09
dc.identifier.issn2047-4830
dc.identifier.issn2047-4849
dc.identifier.urihttps://hdl.handle.net/1721.1/121985
dc.description.abstractDelivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-EB000244–27)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 5-R01-CA132091–04)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-DE016516–03)en_US
dc.language.isoen
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c6bm00683cen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titlePoly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivoen_US
dc.typeArticleen_US
dc.identifier.citationLuo, X. et al. "Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo." Biomaterials Science 1 (January 2017): 38-40 © 2017 The Royal Society of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.relation.journalBiomaterials Scienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-08-09T13:40:38Z
dspace.date.submission2019-08-09T13:40:38Z
mit.journal.volume5en_US
mit.journal.issue1en_US


Files in this item

Thumbnail
Name:
nihms834520.pdf
Size:
219.2Kb
Format:
PDF
Description:
Accepted version
View/Open

This item appears in the following Collection(s)

Show simple item record