A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings

Author(s)
Yesilyurt, Volkan; Veiseh, Omid; Doloff, Joshua C; Li, Jie; Bose, Suman; ... Show more
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Abstract
The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice. Keywords: alginate; dopamine; fibrosis; foreign body response; zwitterionic polymers
Date issued
2016-12
URI
https://hdl.handle.net/1721.1/122007
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Department of Biological Engineering; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Yesilyurt, Volkan et al. "A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings." Advanced Healthcare Materials 6, 4 (December 2016): 1601091 © Wiley
Version: Author's final manuscript
ISSN
2192-2640
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