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dc.contributor.authorAlon, Shahar
dc.contributor.authorHuynh, Grace H.
dc.contributor.authorBoyden, Edward S.
dc.date.accessioned2020-04-14T19:49:45Z
dc.date.available2020-04-14T19:49:45Z
dc.date.issued2019-04
dc.date.submitted2018-06
dc.identifier.issn1742-4658
dc.identifier.urihttps://hdl.handle.net/1721.1/124633
dc.description.abstractThere is a need for single cell analysis methods that enable the identification and localization of different kinds of biomolecules throughout cells and intact tissues, thereby allowing characterization and classification of individual cells and their relationships to each other within intact systems. Expansion microscopy (ExM) is a technology that physically magnifies tissues in an isotropic way, thereby achieving super-resolution microscopy on diffraction-limited microscopes, enabling rapid image acquisition and large field of view. As a result, ExM is well-positioned to integrate molecular content and cellular morphology, with the spatial precision sufficient to resolve individual biological building blocks, and the scale and accessibility required to deploy over extended 3-D objects like tissues and organs. ©2019en_US
dc.description.sponsorshipIARPA (grant no. D16PC00008)en_US
dc.description.sponsorshipNIH (grant no. 1R01MH103910)en_US
dc.description.sponsorshipNIH (grant no. 1RM1HG008525)en_US
dc.description.sponsorshipNIH (grant no. 1R01MH110932)en_US
dc.description.sponsorshipNIH (grant no. 1R01EB024261)en_US
dc.description.sponsorshipNIH (grant no. 1R01NS102727)en_US
dc.description.sponsorshipU.S. Army Research Office (grant no. W911NF1510548)en_US
dc.language.isoen
dc.publisherWileyen_US
dc.relation.isversionof10.1111/febs.14597en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleExpansion microscopy: enabling single cell analysis in intact biological systemsen_US
dc.typeArticleen_US
dc.identifier.citationAlon, Shahar, Grace H. Huynh, and Edward S. Boyden, "Expansion microscopy: enabling single cell analysis in intact biological systems." FEBS journal 286, 8 (April 2019): p. 1482-94 doi 10.1111/febs.14597 2019 ©2019 Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Media Laboratoryen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.relation.journalFEBS journalen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-04-06T16:58:30Z
dspace.date.submission2020-04-06T16:58:32Z
mit.journal.volume286en_US
mit.journal.issue8en_US
mit.licenseOPEN_ACCESS_POLICY
mit.metadata.statusComplete


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