A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion

Author(s)
Horton, Brendan; Spranger, Stefani
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Abstract
Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and reduces responsiveness to immunotherapy.
Date issued
2018-07
URI
https://hdl.handle.net/1721.1/124657
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Immunity
Publisher
Elsevier BV
Citation
Horton, Brendan and Stefani Spranger. "A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion." Immunity 49 (2018): 11-13 © 2018 The Author(s)
Version: Final published version
ISSN
1074-7613
Keywords
Immunology, Immunology and Allergy, Infectious Diseases
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