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dc.contributor.authorWyant, Gregory A.
dc.contributor.authorAbu-Remaileh, Monther
dc.contributor.authorFrenkel, Evgeni M.
dc.contributor.authorLaqtom, Nouf N.
dc.contributor.authorDharamdasani, Vimisha
dc.contributor.authorLewis, Caroline A.
dc.contributor.authorChan, Sze Ham
dc.contributor.authorSabatini, David M.
dc.date.accessioned2020-04-17T13:25:35Z
dc.date.available2020-04-17T13:25:35Z
dc.date.issued2018-04-26
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttps://hdl.handle.net/1721.1/124713
dc.description.abstractThe lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease.We performed quantitative proteomic analyses of rapidly isolated lysosomes and found that nutrient levels and mTOR dynamically modulate the lysosomal proteome. Upon mTORC1 inhibition, NUFIP1 (nuclear fragile Xmental retardation-interacting protein 1) redistributes from the nucleus to autophagosomes and lysosomes. Upon these conditions, NUFIP1 interacts with ribosomes and delivers them to autophagosomes by directly binding to microtubule-associated proteins 1A/1B light chain 3B (LC3B).The starvation-induced degradation of ribosomes via autophagy (ribophagy) depends on the capacity of NUFIP1 to bind LC3B and promotes cell survival.We propose that NUFIP1 is a receptor for the selective autophagy of ribosomes.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01 CA103866)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01 CA129105)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R37 AI47389)en_US
dc.description.sponsorshipUnited States. Department of Defense (Grant W81XWH-15-1-0230)en_US
dc.description.sponsorshipUnited States. Department of Defense (Grant W81XWH-15-1-0337)en_US
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionof10.1126/science.aar2663en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.subjectMultidisciplinaryen_US
dc.titleNUFIP1 is a ribosome receptor for starvation-induced ribophagyen_US
dc.typeArticleen_US
dc.identifier.citationWyant, Gregory A. et al. "NUFIP1 is a ribosome receptor for starvation-induced ribophagy." Science 360 (2018): 751-758 © 2018 The Author(s)en_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-01-30T14:11:15Z
dspace.date.submission2020-01-30T14:11:17Z
mit.journal.volume360en_US
mit.journal.issue6390en_US
mit.licensePUBLISHER_POLICY
mit.metadata.statusComplete


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