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The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Author(s)
Regev, Aviv
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Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/
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Abstract
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
Date issued
2019-04
URI
https://hdl.handle.net/1721.1/125012
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Developmental Cell
Publisher
Elsevier BV
Citation
Taylor, Deanne M. et al. “The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.” Developmental Cell 49 (2019): 10-29 © 2019 The Author(s)
Version: Final published version
ISSN
1534-5807
Keywords
Developmental Biology

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