Direct Electrochemical Carboxylation of Benzylic C–N Bonds with Carbon Dioxide

Author(s)
Yang, Dengtao; Zhu, Minghui; Schiffer, Zachary J.; Williams, Kindle; Song, Xiaojie; ... Show more
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Abstract
We report a direct and efficient electrochemical carboxylation of benzylic C-N bonds with CO₂ at room temperature. The reaction has been successfully applied to both primary and secondary benzylic C-N bonds with the compatibility of a variety of functional groups. This procedure does not require stoichiometric metals, external reducing agents, or sacrificial anodes, making column chromatography unnecessary for product purification. Differential electrochemical mass spectrometry (DEMS) was used to elucidate key intermediates of the electrocarboxylation reaction.
Date issued
2019-04
URI
https://hdl.handle.net/1721.1/125787
Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
ACS Catalysis
Publisher
American Chemical Society (ACS)
Citation
Yang, Deng-Tao et al. "Direct Electrochemical Carboxylation of Benzylic C–N Bonds with Carbon Dioxide." ACS Catalysis 9, 5 (April 2019): 4699–4705 © 2019 American Chemical Society
Version: Author's final manuscript
ISSN
2155-5435
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