Palladium-Catalyzed C–O Cross-Coupling of Primary Alcohols
Author(s)Zhang, Hong; Ruiz-Castillo, Paula; Buchwald, Stephen Leffler
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Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Zhang, Hong, Paula Ruiz-Castillo, and Stephen L. Buchwald. "Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols." Organic Letters 20, 6 (Mar. 2018): p. 1580-83 doi 10.1021/ACS.ORGLETT.8B00325 ©2018 Author(s)
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