| dc.contributor.author | Zhang, Hong | |
| dc.contributor.author | Ruiz-Castillo, Paula | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2020-07-10T16:02:53Z | |
| dc.date.available | 2020-07-10T16:02:53Z | |
| dc.date.issued | 2018-03 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/126129 | |
| dc.description.abstract | Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcohols. For activated substrates, such as electron-deficient aryl halides, the commercially available ligand L2 promotes efficient coupling for a variety of alcohol nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand L8 was developed to improve these challenging C-O bond-forming reactions. | en_US |
| dc.description.sponsorship | National Institutes of Health (grant nos. GM-58160 and GM-122483) | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | 10.1021/ACS.ORGLETT.8B00325 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Palladium-Catalyzed C–O Cross-Coupling of Primary Alcohols | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Zhang, Hong, Paula Ruiz-Castillo, and Stephen L. Buchwald. "Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols." Organic Letters 20, 6 (Mar. 2018): p. 1580-83 doi 10.1021/ACS.ORGLETT.8B00325 ©2018 Author(s) | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2019-12-12T19:19:53Z | |
| dspace.date.submission | 2019-12-12T19:19:55Z | |
| mit.journal.volume | 20 | en_US |
| mit.journal.issue | 6 | en_US |
| mit.metadata.status | Complete | |
