Image-guided neural activity manipulation with a paramagnetic drug

Author(s)
Bricault, Sarah Jean; Barandov, Ali; Harvey, Peter; DeTienne, Elizabeth; Hai, Aviad; ... Show more
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Abstract
Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.
Date issued
2020-01
URI
https://hdl.handle.net/1721.1/126211
Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Bricault, Sarah et al. “Image-guided neural activity manipulation with a paramagnetic drug.” Nature Communications, vol. 11, 2020, article 136 © 2020 The Author(s)
Version: Final published version
ISSN
2041-1723
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