Image-guided neural activity manipulation with a paramagnetic drug
Author(s)Bricault, Sarah Jean; Barandov, Ali; Harvey, Peter; DeTienne, Elizabeth; Hai, Aviad; Jasanoff, Alan Pradip; ... Show more Show less
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Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.
DepartmentMassachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
Springer Science and Business Media LLC
Bricault, Sarah et al. “Image-guided neural activity manipulation with a paramagnetic drug.” Nature Communications, vol. 11, 2020, article 136 © 2020 The Author(s)
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