| dc.contributor.author | Bricault, Sarah Jean | |
| dc.contributor.author | Barandov, Ali | |
| dc.contributor.author | Harvey, Peter | |
| dc.contributor.author | DeTienne, Elizabeth | |
| dc.contributor.author | Hai, Aviad | |
| dc.contributor.author | Jasanoff, Alan Pradip | |
| dc.date.accessioned | 2020-07-15T21:02:39Z | |
| dc.date.available | 2020-07-15T21:02:39Z | |
| dc.date.issued | 2020-01 | |
| dc.identifier.issn | 2041-1723 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/126211 | |
| dc.description.abstract | Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01 DA038642) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant UF1 NS107712) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant U01 NS103470) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant T32 EB019940) | en_US |
| dc.description.sponsorship | Wellcome Trust-MIT Fellowship (105932/Z/14/Z) | en_US |
| dc.language.iso | en | |
| dc.publisher | Springer Science and Business Media LLC | en_US |
| dc.relation.isversionof | 10.1038/s41467-019-13933-5 | en_US |
| dc.rights | Creative Commons Attribution 4.0 International license | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Nature | en_US |
| dc.title | Image-guided neural activity manipulation with a paramagnetic drug | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Bricault, Sarah et al. “Image-guided neural activity manipulation with a paramagnetic drug.” Nature Communications, vol. 11, 2020, article 136 © 2020 The Author(s) | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Nuclear Science and Engineering | en_US |
| dc.relation.journal | Nature Communications | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2020-03-11T17:24:26Z | |
| dspace.date.submission | 2020-03-11T17:24:28Z | |
| mit.journal.volume | 11 | en_US |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Complete | |
