Formulations for trans-tympanic antibiotic delivery

Author(s)
Khoo, Xiaojuan; Simons, Emmanuel John; Chiang, Homer H.; Hickey, Julia M.; Sabharwal, Vishakha; ... Show more
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Abstract
We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. ©2012 Elsevier Ltd.
Date issued
2012-11
URI
https://hdl.handle.net/1721.1/126215
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
Biomaterials
Publisher
Elsevier BV
Citation
Khoo, Xiaojuan et al., "Formulations for trans-tympanic antibiotic delivery." Biomaterials 34, 4 (January 2013): p. 1281-88 doi. 10.1016/j.biomaterials.2012.10.025 ©2012 Authors
Version: Author's final manuscript
ISSN
1878-5905
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