| dc.contributor.author | Khoo, Xiaojuan | |
| dc.contributor.author | Simons, Emmanuel John | |
| dc.contributor.author | Chiang, Homer H. | |
| dc.contributor.author | Hickey, Julia M. | |
| dc.contributor.author | Sabharwal, Vishakha | |
| dc.contributor.author | Pelton, Stephen I. | |
| dc.contributor.author | Rosowski, John J | |
| dc.contributor.author | Langer, Robert | |
| dc.contributor.author | Kohane, Daniel S | |
| dc.date.accessioned | 2020-07-15T22:02:12Z | |
| dc.date.available | 2020-07-15T22:02:12Z | |
| dc.date.issued | 2012-11 | |
| dc.date.submitted | 2012-09 | |
| dc.identifier.issn | 1878-5905 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/126215 | |
| dc.description.abstract | We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. ©2012 Elsevier Ltd. | en_US |
| dc.description.sponsorship | National Institute of Deafness andCommunicative Disorders - NIDCD (Grant Number R21DC009986) | en_US |
| dc.language.iso | en | |
| dc.publisher | Elsevier BV | en_US |
| dc.relation.isversionof | https://dx.doi.org/10.1016/j.biomaterials.2012.10.025 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Formulations for trans-tympanic antibiotic delivery | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Khoo, Xiaojuan et al., "Formulations for trans-tympanic antibiotic delivery." Biomaterials 34, 4 (January 2013): p. 1281-88 doi. 10.1016/j.biomaterials.2012.10.025 ©2012 Authors | en_US |
| dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
| dc.relation.journal | Biomaterials | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2019-09-05T15:47:30Z | |
| dspace.date.submission | 2019-09-05T15:47:32Z | |
| mit.journal.volume | 34 | en_US |
| mit.journal.issue | 4 | en_US |
| mit.metadata.status | Complete | |
