Modular Analysis and Design of Biological Circuits

Author(s)
Grunberg, Theodore W.; Del Vecchio, Domitilla
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Abstract
Modularity has been the subject of intense investigation in systems biology for more than two decades. Whether modularity holds in biological networks is a question that has attracted renewed attention in recent years with the advent of synthetic biology, mostly as a convenient property to perform bottom-up design of complex systems. A number of studies have appeared, which fundamentally challenge modularity as a property of engineered biological circuits. Here, we summarize some of these studies and potential engineering solutions that have been proposed to enable modular composition of biological circuits. ©2019 Elsevier Ltd.
Date issued
2019-12
URI
https://hdl.handle.net/1721.1/126455
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
Current Opinion in Biotechnology
Publisher
Elsevier BV
Citation
Grunberg, Theodore W. and Domitilla Del Vecchio, "Modular Analysis and Design of Biological Circuits." Current Opinion in Biotechnology 63 (June 2020): p. 41-47 doi. 10.1016/j.copbio.2019.11.015 ©2019 Authors
Version: Author's final manuscript
ISSN
1879-0429
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