| dc.contributor.author | Grunberg, Theodore W. | |
| dc.contributor.author | Del Vecchio, Domitilla | |
| dc.date.accessioned | 2020-07-30T21:14:07Z | |
| dc.date.available | 2020-07-30T21:14:07Z | |
| dc.date.issued | 2019-12 | |
| dc.date.submitted | 2019-10 | |
| dc.identifier.issn | 1879-0429 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/126455 | |
| dc.description.abstract | Modularity has been the subject of intense investigation in systems biology for more than two decades. Whether modularity holds in biological networks is a question that has attracted renewed attention in recent years with the advent of synthetic biology, mostly as a convenient property to perform bottom-up design of complex systems. A number of studies have appeared, which fundamentally challenge modularity as a property of engineered biological circuits. Here, we summarize some of these studies and potential engineering solutions that have been proposed to enable modular composition of biological circuits. ©2019 Elsevier Ltd. | en_US |
| dc.description.sponsorship | NSF through CMMI (Award no. 1727189) | en_US |
| dc.language.iso | en | |
| dc.publisher | Elsevier BV | en_US |
| dc.relation.isversionof | https://dx.doi.org/10.1016/J.COPBIO.2019.11.015 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | MIT web domain | en_US |
| dc.title | Modular Analysis and Design of Biological Circuits | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Grunberg, Theodore W. and Domitilla Del Vecchio, "Modular Analysis and Design of Biological Circuits." Current Opinion in Biotechnology 63 (June 2020): p. 41-47 doi. 10.1016/j.copbio.2019.11.015 ©2019 Authors | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
| dc.relation.journal | Current Opinion in Biotechnology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2020-07-08T15:06:40Z | |
| dspace.date.submission | 2020-07-08T15:06:42Z | |
| mit.journal.volume | 63 | en_US |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Complete | |
